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Clinical evidence remains limited to animal studies, but three decades of research and community experimentation have produced consistent patterns

However, intracellular self-assemblies often lead to irreversible accumulation and end-effect cellular responses for therapeutic applications 21,22,23 , including mechanical stress, homeostasis disruption and eventual cell death

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Two samples were discarded because of low read counts (UNTR_002_3 and UNTR_240_3) and principal component analysis (Supplementary Fig

and blood pressure, 111/62 mm Hg